Etude de registre prospective, post-autorisation, multicentrique, menée en ouvert et non interventionnelle pour l'évaluation de l'efficacité de TheraSphere dans la pratique clinique en France. Etude PROACTIF BTG-007996-01
Ouvert
Mis à jour le 25/10/2024
Cancers digestifs (foie)

Informations générales
  • Titre abrégé

    PROACTIF (BTG-007996-01)

  • N° Eudract

    2018-A02412-53

  • Phase de l'essai
    • Phase III

Promoteur
  • Type de promoteur

    Académique / Institutionnel

  • Nom du promoteur

    BTG Biocompatible UK Ltd


Critères d'inclusion
  • - All patients for whom treatment with TheraSphere® has been prescribed and reimbursed in France will be eligible for this study. It is estimated that data from >500 patients will be entered into this registry from approximately 30 sites in France. - non

Critères d'exclusion
  • CONTRAINDICATION FOR THERASPHERE® TREATMENT 1. Patient with measured tumour volume >50% 2. Patients with PV(T)T type IV with complete main portal vein invasion closed to the portal bifurcation and with a poor 99mTc-MAA targeting. Note: Patients with incomplete invasion and good 99mTc-MAA targeting can be considered. 3. Bilirubin >2 mg/dL or >34 ¼mol/L 4. AST/ALT >5 x ULN 5. Ascites > grade 1 under well conducted diuretic treatment (Appendix 7) 6. Child Pugh score > B7 7. Patient with hepatic reserve d"30% of total liver volume and dose to the perfused non-tumoural liver e" 120G (determined with 99mTc-MAA SPECT/SPECT/CT). 8. Any other contraindication listed in the TheraSphere® Instructions for Use (IFU). 9. Patients with infiltrative disease.

Centre investigateur 1
  • Nom du centre

    HCL - Hôpital Edouard Herriot
    Lyon

  • Contact Investigateur

  • Nom

    Frederique GAY

  • Contact ARC/TER/IRC

  • Nom

    Sabine DEBEER


Centre investigateur 2
  • Nom du centre

    HCL - Hôpital de la Croix-Rousse
    Lyon

  • Contact Investigateur

  • Nom

    Agnes RODE

  • Contact ARC/TER/IRC

  • Nom

    Hayette DJOUADI